周期素B1重组兔单抗
Rrmab®兔单抗
货号：bsm-52044R
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概述
产品编号
bsm-52044R
产品类型
重组兔单抗
英文名称
Cyclin B1 Recombinant Rabbit mAb
中文名称
周期素B1重组兔单抗
英文别名
CCNB; Ccnb1-rs1; Ccnb1-rs13; CycB1; Cycb-4; Cycb-5; Cycb1-rs1; CCNB1_HUMAN; CCNB1; CCNB1_MOUSE; Ccn-2; Cycb; CCNB1_RAT;
抗体来源
Rabbit
免疫原
Recombinant human Cyclin B1 protein（1-150aa）
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
2E6
理论分子量
48 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
主要出现在G2期。Cyclin B是细胞周期调节必不可少的条件。 细胞周期素B1是细胞周期调节因子，它的异常表达将导致细胞周期发生紊乱，致使肿瘤形成.
背景资料
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | 1:500-2000 | |
| Flow-Cyt | Human, Mouse | 1μg/Test | |
| ICC/IF | Human | Mouse | 1:50-200 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
CCNB1
蛋白名
G2/mitotic-specific cyclin-B1
亚基
Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization.
亚细胞定位
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome.
翻译后修饰
Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.
Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.
相似性
Belongs to the cyclin family. Cyclin AB subfamily.
功能
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
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