原癌基因蛋白/活化蛋白1重组兔单抗
Rrmab®兔单抗
货号：bsm-52035R
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概述
产品编号
bsm-52035R
产品类型
重组兔单抗
英文名称
c-Jun Recombinant Rabbit mAb
中文名称
原癌基因蛋白/活化蛋白1重组兔单抗
英文别名
AP-1; AP1; c-Jun; cJUN; p39; Junc; JUN_HUMAN; JUN; Activator protein 1 (AP1); Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; JUN_MOUSE; AH119; V-jun avian sarcoma virus 17 oncogene homolog (Jun A); JUN_PIG; JUN_RAT; Rjg-9;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human c Jun: 1-45
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
4A11
理论分子量
43 kDa
检测分子量
43/36 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Oncoproteins/suppressors > Oncoproteins > Transcription factors
Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > SMADs
Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Leucine Zipper
Epigenetics and Nuclear Signaling > Transcription > Transcription Factors
Immunology > Innate Immunity > TLR Signaling
Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Phosphoprotein ELISA kits
Signal Transduction > Signaling Pathway > Nuclear Signaling > SMADs
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
转录调节因子（Transcriptin Regulators）
C-jun(Oncoprotein C-jun：active protein 1)基因与鸟类肉瘤病毒17的转化基因具有同源性，是早期应答基因家族成员之一。主要用于各种恶性肿瘤的研究。C-jun又称应激活化蛋白激酶.
背景资料
C-jun (Oncoprotein C-jun) is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | 1:500-2000 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
JUN
蛋白名
Transcription factor AP-1
亚基
Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3.
亚细胞定位
Nucleus.
翻译后修饰
Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
Acetylated at Lys-271 by EP300.
Acetylated at Lys-271 by EP300.
相似性
Belongs to the bZIP family. Jun subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.
Contains 1 bZIP (basic-leucine zipper) domain.
功能
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
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具体参考文献:bsm-52035R 被引用于2文献中
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