Bcl-xL蛋白重组兔单抗

bsm-52024R

重组兔单抗

Bcl-XL Recombinant Rabbit mAb

Bcl-xL蛋白重组兔单抗

BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52; Bcl(X)L; Bcl-XL; bcl2-L-1; B2CL1_HUMAN; BCL2L1; Apoptosis regulator Bcl-X; B2CL1_MOUSE; B2CL1_RAT; Blc2l;

Rabbit

A synthesized peptide derived from human Bcl 2 L1: 1-233

IgG

Liquid

affinity purified by Protein A

Recombinant

12C5

26 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Bcl X/L蛋白是Bcl蛋白家族的成员之一,是细胞中抑制细胞凋亡的重要分子之一，Bcl-X/L是结构上与Bcl-2具有43%同源性的蛋白，与Bcl-2的作用相同，可抑制细胞凋亡，在肿瘤的发生和发展中起重要作用。

bs-1336P is one synthetic peptide derived from human Bcl-xL.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].