广谱细胞角蛋白PCK单克隆抗体

bsm-34137M

mIHC精品抗体

Pan Cytokeratin Mouse mAb

广谱细胞角蛋白PCK单克隆抗体

CK13; K13; WSN2; K1C16_HUMAN; KRT16; Cytokeratin-16 (CK-16); Keratin-16 (K16); KRT16A; CK14; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS3; EBS4; K14; NFJ; K1C14_HUMAN; KRT14; Cytokeratin-14 (CK-14); Keratin-14 (K14); CK16; FNEPPK; K16; K1CP; NEPPK; PC1; 39.1; CK-17; K17; PC; PC2; PCHC1; K1C17_HUMAN; KRT17; Cytokeratin-17 (CK-17); Keratin-17 (K17); CK-24; K24; KA24; K1C24_HUMAN; KRT24; Cytokeratin-24 (CK-24); Keratin-24 (K24); Type I keratin-24;

Mouse

KLH conjugated synthetic peptide derived from human Pan Cytokeratin

IgG2b, Kappa

Liquid

affinity purified by Protein A

Monoclonal

4C3

42-64 kDa

1mg/ml

Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Proclin300.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P-CK广谱细胞角蛋白（AE1/AE3）主要标记角化上皮、复层鳞状上皮、复层上皮、增生的角化上皮和单层上皮，用于鳞癌，各种腺癌 、移行上皮癌，小细胞癌，恶性间皮瘤、生殖细胞肿瘤，部分滑膜肉瘤、平滑肌肉瘤等表达。

Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. The cytokeratins are encoded by a family encompassing 30 genes. Among them, 20 are epithelial genes and the remaining 10 are specific for trichocytes. In the cytoplasm, the keratin filaments conform a complex network which extends from the surface of the nucleus to the cell membrane. Numerous accessory proteins are involved in the genesis and maintenance of such structure. This association between the plasma membrane and the nuclear surface provides important implications for the organization of the cytoplasm and cellular communication mechanisms. Apart from the relatively static functions provided in terms of supporting the nucleus and providing tensile strength to the cell, the cytokeratin networks undergo rapid phosphate exchanges mediated depolymerization, with important implications in the more dynamic cellular processes such as mitosis and post-mitotic period, cell movement and differentiation. Cytokeratins interact with desmosomes and hemidesmosomes, thus collaborating to cell-cell adhesion and basal cell-underlying connective tissue connection.