叉头蛋白P3重组兔单抗
Rrmab®兔单抗
货号：bsm-60760R
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概述
产品编号
bsm-60760R
产品类型
重组兔单抗
英文名称
FOXP3 Recombinant Rabbit mAb
中文名称
叉头蛋白P3重组兔单抗
英文别名
AIID; DIETER; IPEX; JM2; PIDX; XPID; scurfin; sf; RGD1562112; FOXP3_HUMAN; FOXP3; FOXP3_MOUSE; D3ZKI1_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human FOXP3
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5C7
理论分子量
47 kDa
浓度
1mg/ml
储存液
PBS, Glycerol, BSA.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
FoxP3
蛋白名
Forkhead box protein P3
亚基
Interacts with IKZF3.
亚细胞定位
Nucleus (Potential).
翻译后修饰
Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1.
疾病
Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.
相似性
Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain.
Contains 1 fork-head DNA-binding domain.
功能
Probable transcription factor. Plays a critical role in the control of immune response.
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