E2F8 Antibody Blocking Peptide (合成多肽) | Bioss

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货号：bs-4265P
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概述

产品编号
bs-4265P
英文名称
E2F8 Antibody Blocking Peptide
中文名称
转录因子E2F8封闭多肽
英文别名
E2F 8; E2F family member 82; E2F transcription factor 8; E2F-8; E2f8; E2F8_HUMAN; FLJ23311; Transcription factor E2F8.
纯化方法
HPLC
研究领域

Cancer > Cancer Metabolism > Transcriptional control

Epigenetics and Nuclear Signaling > Transcription > Other factors

Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism > Molecular processes > Transcriptional control

Metabolism > Types of disease > Cancer

活性
Not tested
保存条件
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

Entrez Gene : 79733 Human

Entrez Gene : 108961 Mouse

Entrez Gene : 308607 Rat

Omim : 612047 Human

SwissProt : A0AVK6 Human

SwissProt : Q58FA4 Mouse

Unigene : 523526 Human

Unigene : 240566 Mouse

Unigene : 395068 Mouse

背景资料
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012].

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靶标

基因名
E2F8
蛋白名
Transcription factor E2F8
亚基
Forms heterodimers with E2F7 and, to a lesser extent, homodimers. Dimerization is important for DNA binding.
亚细胞定位
Nucleus.
相似性
Belongs to the E2F/DP family
功能
Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.

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