EAAT3 Rabbit pAb (一抗) | Bioss
货号：bs-21311R
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概述
产品编号
bs-21311R
英文名称
EAAT3 Rabbit pAb
中文名称
胶质细胞谷氨酸运载蛋白3/神经/上皮细胞谷氨酸运载蛋白抗体
英文别名
DCBXA; EAAC1; EAAT3; SCZD18; hEAAC1; D130048G10Rik; EAAC2; MEAAC1; REAAC1; EAA3_HUMAN; SLC1A1; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1; EAA3_MOUSE; EAA3_RAT; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Excitatory amino acid transporter 3; excitatory amino acid carrier 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human EAAT3 : 101-200/524 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
58 kDa
检测分子量
58 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
胶质细胞谷氨酸运载蛋白3又称：神经/上皮细胞谷氨酸运载蛋白
背景资料
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human | 1:500-2000 |
交叉反应
交叉反应: Mouse (predicted: Human)
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靶标
基因名
SLC1A1
蛋白名
Excitatory amino acid transporter 3
亚基
Interacts with ARL6IP5/PRAF3.
亚细胞定位
Membrane; Multi-pass membrane protein.
组织特异性
Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).
翻译后修饰
Glycosylated.
相似性
Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.
功能
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
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