乙酰辅酶A羧化酶重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
乙酰辅酶A羧化酶重组兔单抗
货号:bsm-52486R
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概述

产品编号
bsm-52486R
产品类型
重组兔单抗
英文名称
ACACA Recombinant Rabbit mAb
中文名称
乙酰辅酶A羧化酶重组兔单抗
英文别名
ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta; HACC275; A530025K05Rik; Acac; Acc1; Gm738; ACACA_HUMAN; ACACA; Acetyl-Coenzyme A carboxylase alpha (ACC-alpha); 6.4.1.2; ACCA; ACACA_MOUSE; ACC-alpha; Acetyl-CoA carboxylase 265; ACACA_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Acetyl CoA Carboxylase 1(ACC1)
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
2B5
理论分子量
265 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, MouseRat1:500-1000
IHC-PHuman, Mouse, Rat1:50-200
IHC-FHuman, Mouse, Rat1:50-200
IFHuman, Mouse, Rat1:50-200

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
ACACA
蛋白名
Acetyl-CoA carboxylase 1
亚基
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
亚细胞定位
Cytoplasm.
组织特异性
Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
翻译后修饰
Phosphorylation on Ser-1263 is required for interaction with BRCA1.
疾病
Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.
相似性
Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.
功能
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

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