基质金属蛋白酶-9重组兔单抗

概述

产品编号

bsm-54040R

产品类型

重组兔单抗、mIHC精品抗体

英文名称

MMP9 Recombinant Rabbit mAb

中文名称

基质金属蛋白酶-9重组兔单抗

英文别名

CLG4B; GELB; MANDP2; MMP-9; B/MMP9; Gel B; pro-MMP-9; MMP9_CANLF; MMP9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B (GELB); 3.4.24.35; MMP9_HUMAN; MMP9_MOUSE;

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human MMP9: 100-165/707

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

7D6

理论分子量

100 kDa

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

SWISS

P14780

Gene ID

4318

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 403885 Dog

Entrez Gene : 4318 Human

Entrez Gene : 17395 Mouse

Entrez Gene : 81687 Rat

Omim : 120361 Human

SwissProt : O18733 Dog

SwissProt : P14780 Human

SwissProt : P41245 Mouse

产品介绍

MMP9亦称IV型胶原酶或明胶酶B，其主要功能为降解IV型胶原。因而它在肿瘤细胞突破基底膜屏障和浸润转移中起重要作用。目前主要用于各种恶性肿瘤(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)中的基底膜检测与转移浸润的研究。细胞外基质在维持正常组织结构与功能以及细胞生长和分化过程中起重要作用。细胞外基质动态平衡的失调与肿瘤细胞侵袭、转移和复发密切相关，基质金属蛋白酶(MMP9)是细胞外基质的降解酶，可降解Ⅳ、Ⅴ、Ⅸ、Ⅺ型胶原，在肿瘤的浸润、转移过程中起重要作用，近年为肿瘤研究的热点。

背景资料

bs-7059P is one synthetic peptide derived from human MMP-9.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008].

产品应用

应用	已检合格种属	预测种属	推荐稀释比例
WB	Human, Rat	Mouse	1:2000-20000
IHC-P	Human, Mouse, Rat		1:200-1000
IHC-F	Human, Mouse, Rat		1:200-1000
IF	Human, Mouse, Rat		1:200-1000

交叉反应

交叉反应: Human, Mouse, Rat

靶标

基因名

Mmp9

蛋白名

Matrix metalloproteinase-9

亚基

Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.

亚细胞定位

Secreted; extracellular space; extracellular matrix.

组织特异性

Produced by normal alveolar macrophages and granulocytes. Post-translational modifications : Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.

翻译后修饰

Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.

疾病

Defects in MMP9 are the cause of metaphyseal anadysplasia type 2 (MANDP2) [MIM:613073]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.

相似性

Belongs to the peptidase M10A family.
Contains 3 fibronectin type-II domains.
Contains 4 hemopexin-like domains.

功能

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

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基质金属蛋白酶-9重组兔单抗

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交叉反应

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