细胞色素cP450 CYP26A1重组兔单抗

bsm-54341R

重组兔单抗

CYP26A1 Recombinant Rabbit mAb

细胞色素cP450 CYP26A1重组兔单抗

CP26; CYP26; P450RAI; P450RAI1; CP26A_HUMAN; CYP26A1; Cytochrome P450 retinoic acid-inactivating 1 (Cytochrome P450RAI | hP450RAI); Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome; 1.14.13.-;

Rabbit

A synthesized peptide derived from human Cytochrome P450 26A1: 250-450

IgG

Liquid

affinity purified by Protein A

Recombinant

11A1

48 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.