VCAM1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-52248R

重组兔单抗、mIHC精品抗体

VCAM1 Recombinant Rabbit mAb

血管内皮细胞粘附分子（CD106）重组兔单抗

CD106; INCAM-100; VCAM1_HUMAN; VCAM1; V-CAM 1; VCAM-1; vascular cell adhesion molecule 1

Rabbit

KLH conjugated synthetic peptide derived from human VCAM-1: 651-739/739

IgG

Liquid

affinity purified by Protein A

Recombinant

24D1

81 kDa

100 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

VCAM 1（CD106）是一种膜相关蛋白，分布于血管内皮及其周围的淋巴细胞、单核细胞、嗜酸性粒细胞和中性粒细胞。Anti-VCAM-1主要用于各种组织中血管内皮的检测。

VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.

VCAM1

Vascular cell adhesion protein 1

Binds to ECMV-D capsid proteins and acts as a receptor for this virus.

Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.

Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.

Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.