EDR1/PHC1 Antibody Blocking Peptide (合成多肽) | Bioss

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货号：bs-12302P
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概述

产品编号
bs-12302P
英文名称
EDR1/PHC1 Antibody Blocking Peptide
中文名称
早期发育调控蛋白1/EDR1封闭多肽
英文别名
Early development regulatory protein 1; EDR1 PH1; hPH1; mPH1; PH1; EDR1; Polyhomeotic-like protein 1; Rae28; PHC1_HUMAN.
纯化方法
HPLC
研究领域

Epigenetics and Nuclear Signaling > Chromatin Remodeling > Polycomb Silencing > PRC1

Epigenetics and Nuclear Signaling > Chromatin Remodeling > Polycomb Silencing > PRC2

Stem Cells > Hematopoietic Progenitors > Intracellular Molecules

活性
Not tested
保存条件
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

Entrez Gene : 1911 Human

Omim : 602978 Human

SwissProt : P78364 Human

Unigene : 305985 Human

背景资料
PHC1 is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.

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靶标

基因名
PHC1
蛋白名
Polyhomeotic-like protein 1
亚细胞定位
Nuclear.
相似性
Contains 1 FCS-type zinc finger.
Contains 1 SAM (sterile alpha motif) domain.
功能
PHC1 is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The Polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators, such as Hox genes, and thus are essential for proper development. PHC1 is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. PHC1, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.

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