兔抗桥粒芯糖蛋白2单克隆抗体
Rrmab®兔单抗
货号：bsm-54310R
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概述
产品编号
bsm-54310R
产品类型
重组兔单抗
英文名称
Desmoglein 2 Recombinant Rabbit mAb
中文名称
兔抗桥粒芯糖蛋白2单克隆抗体
英文别名
CDHF5; HDGC; D18Ertd293e; DSG2_HUMAN; DSG2; Cadherin family member 5; DSG2_MOUSE;
抗体来源
Rabbit
免疫原
Recombinant protein within C-terminal human Desmoglein 2
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7D6
理论分子量
150 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| Flow-Cyt | Human | 1:50-100 | |
| ICC/IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
DSG2
蛋白名
Desmoglein-2
亚基
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
组织特异性
All of the tissues tested and carcinomas.
疾病
Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
相似性
Contains 4 cadherin domains.
功能
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
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