Recombinant rat IFN Gamma protein, C-His (重组蛋白) | Bioss
货号：bs-41062P
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概述
产品编号
bs-41062P
英文名称
Recombinant rat IFN Gamma protein, C-His
中文名称
重组大鼠干扰素-γ/IFN-γ蛋白
英文别名
IFNG; IFG; IFI; IFN-γ; IFN γ; IFN Immune; IFN-gamma; IFNG; IFNG_RAT; Immune Interferon; Interferon gamma; Interferon Gamma Precursor; Macrophage Activating Factor; MAF; T Cell Interferon; Type II Interferon; Recombinant rat IFN Gamma protein, C-His
性状
Lyophilized or Liquid
纯化方法
AC
理论分子量
16
浓度
＞0.5 mg/ml
储存液
20mM Tris-HCl (pH8.0) 10% Glycerol.
研究领域
活性
Not tested
序列
23-156/156
标签
C-His
纯度
>95% as determined by SDS-PAGE
内毒素
Not analyzed
表达系统
E.coli
复溶
Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
保存条件
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Mammalian Interferon gamma is mainly produced by T lymphocytes and NK cells. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses,including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak antiviral and antiproliferative activity, and poteniates the antiviral and anti tumor effects of IFN alpha / beta (type I interferon). It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. Labile at pH 2.
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靶标
基因名
IFNG
蛋白名
Interferon gamma
亚基
Homodimer.
亚细胞定位
Secreted.
组织特异性
Released primarily from activated T lymphocytes.
翻译后修饰
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
疾病
In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
相似性
Belongs to the type II (or gamma) interferon family.
功能
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.