英文别名
alpha 2C Adrenergic Receptor; Adra 2c; Adra 2c; ADRA2C; ADRA2L2; ADRA2L2; ADRA2RL2; ADRA2RL2; ADRARL2; ADRARL2; Adrenergic alpha 2C receptor; Adrenoceptor alpha 2C; Alpha 2C adrenergic receptor; Alpha 2C adrenergic receptor subtype C4; Alpha 2C adrenoceptor; Alpha 2C adrenoreceptor; Alpha 2CAR; alpha2 AR C4; alpha2 AR C4; alpha2 C4; alpha2 C4; alpha2C; alpha2C; ALPHA2CAR; alpha2cii-adrenergic receptor; Subtype alpha2 C4; Subtype alpha2 C4; ADA2C_HUMAN.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]