TJP2 Rabbit pAb (一抗) | Bioss
货号：bs-4844R
产品详情
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概述
产品编号
bs-4844R
产品类型
宠物抗体、模式动物抗体、农牧业/家禽抗体
英文名称
TJP2 Rabbit pAb
中文名称
紧密连接蛋白2抗体
英文别名
C9DUPq21.11; DFNA51; DUP9q21.11; FHCA1; PFIC4; X104; ZO2; ZO-2; ZO2_HUMAN; TJP2; Tight junction protein ZO-2; Zona occludens protein 2; Zonula occludens protein 2; ZO2_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human TJP2: 551-650/1190
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
131 kDa
检测分子量
170 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat, Rabbit, Sheep, Cow, Chicken, Dog, GuineaPig, Horse, Danio rerio | 1:500-2000 |
| IHC-P | Human, Rat | Mouse, Rabbit, Sheep, Cow, Chicken, Dog, GuineaPig, Horse, Danio rerio | 1:100-500 |
| IHC-F | Human, Rat | Mouse, Rabbit, Sheep, Cow, Chicken, Dog, GuineaPig, Horse, Danio rerio | 1:100-500 |
| IF | Human, Rat | Mouse, Rabbit, Sheep, Cow, Chicken, Dog, GuineaPig, Horse, Danio rerio | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Sheep, Cow, Chicken, Dog, GuineaPig, Horse, Danio rerio)
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靶标
基因名
TJP2
蛋白名
Tight junction protein ZO-2
亚基
Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction with SAFB occurs in the nucleus. Interacts with SCRIB.
亚细胞定位
Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Nucleus. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.
组织特异性
This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.
疾病
Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
相似性
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.
Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.
功能
Plays a role in tight junctions and adherens junctions
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