ABCB5 Antibody Blocking Peptide (合成多肽) | Bioss

货号:bs-1604P
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概述

产品编号
bs-1604P
英文名称
ABCB5 Antibody Blocking Peptide
中文名称
ATP结合蛋白家族5封闭多肽
英文别名
ATP-binding cassette sub-family B member 5; ABCB 5; ABCB5alpha; ABCB5beta; ATP binding cassette sub family B (MDR/TAP) member 5; ATP binding cassette sub family B member 5; EST422562; P glycoprotein ABCB5; ABCB5_HUMAN.
纯化方法
HPLC
活性
Not tested
保存条件
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

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靶标

基因名
ABCB5
蛋白名
ATP-binding cassette sub-family B member 5
亚细胞定位
Cell membrane; Multi-pass membrane protein.
组织特异性
Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.
相似性
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 2 ABC transporter domains.
功能
Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.

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