Recombinant human Beta-2-microglobulin, C-His (重组蛋白) | Bioss
货号：bs-41176P
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概述
产品编号
bs-41176P
英文名称
Recombinant human Beta-2-microglobulin, C-His
中文名称
重组人β2-微球蛋白/β2微球蛋白
英文别名
B2M; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; Beta 2 microglobin; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; CDABP0092. ;Recombinant human Beta-2-microglobulin, C-His
性状
Lyophilized or Liquid
纯化方法
AC
理论分子量
12
检测分子量
12 kDa
浓度
＞0.5 mg/ml
储存液
20mM Tris-HCl (pH8.0) with 150mM NaCl.
研究领域
活性
Not tested
序列
21-119/119
标签
C-His
纯度
>95% as determined by SDS-PAGE
内毒素
Not analyzed
表达系统
E.coli
复溶
Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
保存条件
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
小鼠抗人β2微球蛋白在中枢神经系统感染、肿瘤及全身性自身免疫性疾病患者脑脊液中，会出现β2MG蛋白不同程度的增高。
背景资料
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009].
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靶标
基因名
B2M
蛋白名
beta-2-microglobulin
亚基
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.
亚细胞定位
Secreted. Note=Detected in serum and urine.
翻译后修饰
Glycation of Ile-21 is observed in long-term hemodialysis patients.
疾病
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
相似性
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
功能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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