MAPK/ERK激酶3重组兔单抗

bsm-52709R

重组兔单抗

MEKK3 Recombinant Rabbit mAb

MAPK/ERK激酶3重组兔单抗

CCM5; MAPKKK3; MEKK3; mKIAA4031; M3K3_HUMAN; MAP3K3; MAPK/ERK kinase kinase 3 (MEK kinase 3 | MEKK 3); 2.7.11.25; M3K3_MOUSE;

Rabbit

A synthesized peptide derived from human MEKK3: 1-47/626

IgG

Liquid

affinity purified by Protein A

Recombinant

5C1

71 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]