CD8重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
CD8重组兔单抗
货号:bsm-60735R
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概述

产品编号
bsm-60735R
产品类型
重组兔单抗
英文名称
CD8 Recombinant Rabbit mAb
中文名称
CD8重组兔单抗
英文别名
CD8; CD8alpha; IMD116; Leu2; p32; Ly-2; Ly-35; Ly-B; Lyt-2; CD8A_HUMAN; CD8A; T-lymphocyte differentiation antigen T8/Leu-2; MAL; CD8A_MOUSE; T-cell surface glycoprotein Lyt-2; Lyt2; G1SX34_RABIT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human CD8
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
D5A7
理论分子量
27 kDa
储存液
PBS, Glycerol, BSA.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
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产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman1:500-2000
IHC-PHuman1:100-500
IHC-FHuman1:100-500
IFHuman1:100-500

交叉反应

交叉反应: Human

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靶标

基因名
CD8A
蛋白名
T-cell surface glycoprotein CD8 alpha chain
亚基
In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers.
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver.
相似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
功能
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

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