ADAM17 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
货号：bs-4236R
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常见问题
概述
产品编号
bs-4236R
英文名称
ADAM17 Rabbit pAb
中文名称
肿瘤坏死因子α转换酶抗体
英文别名
ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE; ADA17_HUMAN; ADAM17; ADAM 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; 3.4.24.86; ADA17_MOUSE; ADA17_RAT; ADAM metallopeptidase domain 17; tumor necrosis factor, alpha, converting enzyme; cartilage snake venom-like protease; TNF-alpha convertase enzyme; a disintegrin and metalloproteinase 17
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human ADAM17: 201-300/824 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
68/91 kDa
检测分子量
100-110 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Response to hypoxia
Cancer > Invasion/microenvironment > ECM > Extracellular matrix > ADAM protein family
Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Metalloprotease > ADAMs
Metabolism > Pathways and Processes > Metabolism processes > Hypoxia
Metabolism > Types of disease > Cancer
Metabolism > Types of disease > Neurodegenerative disease
Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus
Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| Flow-Cyt | Human, Mouse, Rat | 1μg/Test | |
| ICC/IF | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ADAM17
蛋白名
Disintegrin and metalloproteinase domain-containing protein 17
亚基
Interacts with MAD2L1, MAPK14 and MUC1.
亚细胞定位
Membrane.
组织特异性
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
相似性
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 1 peptidase M12B domain.
功能
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).
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