phospho-c-Jun(Thr93) Antibody Blocking Peptide (合成多肽) | Bioss

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货号：bs-12913P
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概述

产品编号
bs-12913P
英文名称
phospho-c-Jun(Thr93) Antibody Blocking Peptide
中文名称
磷酸化原癌基因c-Jun封闭多肽
英文别名
c-Jun (phospho T93); c-Jun (phospho Thr93); p-c-Jun (Thr93); Jun oncogene; JUN; Activator Protein 1; AP 1; AP1; AP-1; Enhancer Binding Protein AP1; Jun Activation Domain Binding Protein; JUN protein; JUNC; p39; Proto oncogene cJun; Transcription Factor AP1; V jun avian sarcoma virus 17 oncogene homolog; vJun Avian Sarcoma Virus 17 Oncogene Homolog; JUN_HUMAN; Transcription factor AP-1; Activator 1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog.
纯化方法
HPLC
研究领域

Cancer > Oncoproteins/suppressors > Oncoproteins > Transcription factors

Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > SMADs

Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Leucine Zipper

Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

Immunology > Innate Immunity > TLR Signaling

Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Phosphoprotein ELISA kits

Signal Transduction > Signaling Pathway > Nuclear Signaling > SMADs

活性
Not tested
保存条件
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

Entrez Gene : 3725 Human

Entrez Gene : 16476 Mouse

Entrez Gene : 396913 Pig

Entrez Gene : 24516 Rat

Omim : 165160 Human

SwissProt : P05412 Human

SwissProt : P05627 Mouse

SwissProt : P56432 Pig

SwissProt : P17325 Rat

Unigene : 525704 Human

Unigene : 696684 Human

Unigene : 275071 Mouse

Unigene : 93714 Rat

产品介绍
转录调节因子（Transcriptin Regulators） C-jun(Oncoprotein C-jun：active protein 1)基因与鸟类肉瘤病毒17的转化基因具有同源性，是早期应答基因家族成员之一。主要用于各种恶性肿瘤的研究。C-jun又称应激活化蛋白激酶.
背景资料
C-jun (Oncoprotein C-jun) is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.

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靶标

基因名
JUN
蛋白名
Transcription factor AP-1
亚基
Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3.
亚细胞定位
Nucleus.
翻译后修饰
Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
Acetylated at Lys-271 by EP300.
相似性
Belongs to the bZIP family. Jun subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.
功能
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

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