AICDA Rabbit pAb (一抗) | Bioss

bs-7855R

AICDA Rabbit pAb

活化诱导胞嘧啶核苷脱氨酶抗体

AID; ARP2; CDA2; HEL-S-284; HIGM2; AICDA_HUMAN; AICDA; Activation-induced cytidine deaminase (AID); Cytidine aminohydrolase; 3.5.4.38; AICDA_MOUSE; activation induced cytidine deaminase; activation-induced cytidine deaminase

Rabbit

KLH conjugated synthetic peptide derived from human AICDA: 101-198/198

IgG

Liquid

affinity purified by Protein A

Polyclonal

24 kDa

24 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. Tissue specificity:Strongly expressed in lymph nodes and tonsils. Involvement in disease:Defects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 (HIGM2); also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.