KLF4重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28，RR26012026-01-04~2026-02-28，TR
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KLF4重组兔单抗
货号：bsm-52850R
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概述

产品编号
bsm-52850R
产品类型
重组兔单抗
英文名称
KLF4 Recombinant Rabbit mAb
中文名称
KLF4重组兔单抗
英文别名
EZF; GKLF; Zie; KLF4_HUMAN; KLF4; Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor; KLF4_MOUSE;
抗体来源
Rabbit
免疫原
Recombinant protein within human KLF4 aa 1-500
亚型
IgG
性状
Size : 25ul/50ul/100ul/200ul
Liquid

Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
6C5
理论分子量
56 kDa
浓度
1mg/ml
储存液
Size : 25ul/50ul/100ul/200ul
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS
研究领域

Cancer > Oncoproteins/suppressors > Oncoproteins > Transcription factors

Cancer > Oncoproteins/suppressors > Tumor suppressors

Cardiovascular > Angiogenesis > Endothelial Cell Markers

Cardiovascular > Heart > Hypertrophy > Transcription factors

Developmental Biology > Embryogenesis > Embryonic stem cells > Surface molecules

Epigenetics and Nuclear Signaling > Cell cycle > Cell Cycle Inhibitors

Epigenetics and Nuclear Signaling > Cell cycle > Cell Differentiation

Epigenetics and Nuclear Signaling > Transcription > Domain Families > Krueppel like factor

Epigenetics and Nuclear Signaling > Transcription > Krueppel like factor

Epigenetics and Nuclear Signaling > Transcription > Other factors

Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

Stem Cells > Embryonic Stem Cells > Intracellular

SWISS
O43474
Gene ID
9314
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

Entrez Gene : 9314 Human

Entrez Gene : 16600 Mouse

Omim : 602253 Human

SwissProt : O43474 Human

SwissProt : Q60793 Mouse

Unigene : 376206 Human

Unigene : 4325 Mouse

产品介绍
Klf4（原称GKLF）调节体外細胞的增生与分化，有学者认为：KLF4可能参与消化系统肿瘤的发生及发展过程，多表达与结肠。又称：上皮锌指转录因子（上皮锌指蛋白）Surface skin layer zinc finger protein。
背景资料
KLF4 is a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene. It binds the CACCC core sequence. KLF4 may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney. KLF4 also has roles as both an oncogene and a tumor suppressor.
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产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, MouseRat1:500-2000
IHC-PHuman, Mouse, Rat1:100-500
IHC-FHuman, Mouse, Rat1:100-500
IFHuman, Mouse, Rat1:100-500
Flow-CytHumanMouse, Rat1ug/Test
ICC/IFHumanMouse, Rat1:100-500

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
KLF4
蛋白名
Krueppel-like factor 4
亚基
Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain).
亚细胞定位
Nucleus.
翻译后修饰
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
相似性
Belongs to the krueppel C2H2-type zinc-finger protein family.
功能
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

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