This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
Human, Rat
1:500-2000
IHC-P
Human
Mouse, Rat
1:100-500
IHC-F
Human
Mouse, Rat
1:100-500
IF
Mouse
Human, Rat
1:100-500
交叉反应
交叉反应: Human, Mouse (predicted: Rat)
相关产品
暂无相关产品
靶标
基因名
CEP120
蛋白名
Centrosomal protein of 120 kDa
亚细胞定位
Cytoplasm > cytoskeleton > centrosome. Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo.
相似性
Belongs to the CEP120 family.
功能
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis.