Human LDL (天然蛋白) | Bioss

bs-2200P

Human LDL

人低密度脂蛋白

apolipoprotein; low density; low density lipoprotein; Low density lipoprotein; Lipoprotein, low density from human plasma.

Liquid

>1.0 mg/ml

Yes

Purified native protein

Not analyzed

Stored at 2-8℃. Avoid repeated freeze/thaw cycles. This product is stable for 8 weeks after open when handled aseptically.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

LDL (low-density lipoprotein) is a type of lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues. LDL enables fats and cholesterol to move within the water based solution of the blood stream. LDL also regulates cholesterol synthesis at these sites. The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells.