EAA1 Antibody Blocking Peptide (合成多肽) | Bioss

货号:bs-12560P
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概述

产品编号
bs-12560P
英文名称
EAA1 Antibody Blocking Peptide
中文名称
谷氨酸受体KA1封闭多肽
英文别名
EAA 1; EAA1; Excitatory amino acid receptor 1; Glutamate receptor; Glutamate receptor ionotropic kainate 4; Glutamate receptor ionotropic kainate 4 precursor; Glutamate receptor KA 1; Glutamate receptor KA 1precursor; Glutamate receptor KA-1; Glutamate receptor KA1; Glutamate receptor, ionotropic kainate 4; GRIK 4; GRIK; GRIK4; GRIK4_HUMAN; ionotropic kainate 4; KA 1; KA1; OTTHUMP00000045951; OTTHUMP00000231881.
纯化方法
HPLC
活性
Not tested
保存条件
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of the structurally related subunits GluR-1 to -7, KA1 and KA2. KA1 (also designated EEA1) and KA2 (also designated EEA2) form heteromeric receptors with GluR subunits when coexpressed, forming ion channels with various properties . The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate.

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靶标

基因名
GRIK4
蛋白名
Glutamate receptor ionotropic, kainate 4
亚基
Forms a heteromeric channel with GRIK1 or GRIK3.
亚细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
相似性
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
功能
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

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