FBXL5 Rabbit pAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
货号：bs-8468R
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概述
产品编号
bs-8468R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
FBXL5 Rabbit pAb
中文名称
FBXL5蛋白抗体
英文别名
FBL4; FBL5; FLR1; Fir4; FBXL5_HUMAN; FBXL5; F-box and leucine-rich repeat protein 5; F-box protein FBL4/FBL5; p45SKP2-like protein; FBXL5_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human FBXL5: 31-130/691
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
79 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:50-200 |
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1ug/Test |
| ICC/IF | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:50-100 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse)
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靶标
基因名
FBXL5
蛋白名
F-box/LRR-repeat protein 5
亚基
Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with ACO1/IRP1, IREB2/IRP2; the interaction depends on the 4Fe-4S cluster. Interacts with DCTN1/p150-glued.
亚细胞定位
Cytoplasm, perinuclear region.
翻译后修饰
Ubiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor.
相似性
Contains 1 F-box domain.
Contains 7 LRR (leucine-rich) repeats.
Contains 7 LRR (leucine-rich) repeats.
功能
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
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