HES1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
Rrmab?兔单抗
货号：bsm-52568R
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概述
产品编号
bsm-52568R
产品类型
重组兔单抗
英文名称
HES1 Recombinant Rabbit mAb
中文名称
转录因子HES-1重组兔单抗
英文别名
HAIRY1; HES1; c-Hey1; c-hairy-1; c-hairy1A; HES-1; HHL; HRY; bHLHb39; HES1_CHICK; C-HAIRY1; Hairy and enhancer of split 1; HES1_BOVIN; HES1_HUMAN; Class B basic helix-loop-helix protein 39 (bHLHb39); Hairy homolog; Hairy-like protein (hHL); HL; HES1_MOUSE; HES1_RAT; Hairy-like protein; RHL;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human HES1: 200-280/280
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
6E11
理论分子量
30 kDa
检测分子量
30 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| Flow-Cyt | Human | Mouse, Rat | 1:50-100 |
| ICC/IF | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
HES1
蛋白名
Transcription factor HES-1
亚基
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE.
亚细胞定位
Nucleus.
相似性
Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain.
功能
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity.
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