间皮素重组兔单抗
Rrmab®兔单抗
货号：bsm-60005R
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概述
产品编号
bsm-60005R
产品类型
重组兔单抗
英文名称
Mesothelin Recombinant Rabbit mAb
中文名称
间皮素重组兔单抗
英文别名
MPF; SMRP; MSLN_HUMAN; MSLN; CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Mesothelin: 550-570/630
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
1A14
理论分子量
64 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
间皮素（mesothelin, MSLN）是一种相对分子量：64kDa的细胞表面糖蛋白, 在间皮瘤、 卵巢癌、 胰腺癌等恶性肿瘤中有较高的表达。主要用于恶性肿瘤的研究。
背景资料
Mesothelin(MSLN)may play a role in cell adhesion and cell shape dynamics; human homolog highly expressed in renal cell carcinoma. malignant tumors, such as a skin lump, ovary cancer and the pancreas cancer...etc..Mainly used for the research of the malignant tumor.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
MSLN
蛋白名
Mesothelin
亚基
Interacts with MUC16.
亚细胞定位
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.
Megakaryocyte-potentiating factor: Secreted.
Isoform 3: Secreted.
Megakaryocyte-potentiating factor: Secreted.
Isoform 3: Secreted.
组织特异性
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
翻译后修饰
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
相似性
Belongs to the mesothelin family.
功能
Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
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