Histone H1b are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
IHC-P
Human
Rabbit, Dog
1:100-500
IHC-F
Human
Rabbit, Dog
1:100-500
IF
Human
Rabbit, Dog
1:100-500
交叉反应
交叉反应: Human (predicted: Rabbit, Dog)
相关产品
暂无相关产品
靶标
基因名
H1-4
蛋白名
Histone H1.4
亚细胞定位
Nucleus. Chromosome.
翻译后修饰
Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1.
相似性
Belongs to the histone H1/H5 family. Contains 1 H15 (linker histone H1/H5 globular) domain.
功能
Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.