nNOS Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

2026-05-01~2026-06-30,AB2605
nNOS Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
货号:bs-10197R
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概述

产品编号
bs-10197R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
nNOS Rabbit pAb
中文名称
一氧化氮合成酶-1(神经型)抗体
英文别名
IHPS1; N-NOS; NC-NOS; NOS; bNOS; nNOS; NOS1_HUMAN; NOS1; Constitutive NOS; NOS type I; Neuronal NOS (N-NOS | nNOS); Nitric oxide synthase, brain (bNOS); Peptidyl-cysteine S-nitrosylase NOS1; 1.14.13.39; nitric oxide synthase 1; nitric oxide synthase 1 (neuronal)
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human nNos/NOS-1: 601-700/1434
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
130 kDa
检测分子量
150 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
一氧化氮合成酶-1催化生物体内一氧化氮(NO)生成的酶。分神经型一氧化氮合成的酶(nNOS or NOS1)、诱导型一氧化氮合成的酶(iNOS or NOS2)、内皮型一氧化氮合成的酶(eNOS or NOS3)。此抗体识别分子量为150kDa的神经型一氧化氮合成的酶。
背景资料
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011].
一氧化氮合成酶-1(神经型)抗体-bs-10197R一氧化氮合成酶-1(神经型)抗体-bs-10197R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBMouseHuman, Rat, Pig, Sheep, Cow, Chicken, Dog1:500-2000
IHC-PMouseHuman, Rat, Pig, Sheep, Cow, Chicken, Dog1:100-500
IHC-FMouseHuman, Rat, Pig, Sheep, Cow, Chicken, Dog1:100-500
IFMouseHuman, Rat, Pig, Sheep, Cow, Chicken, Dog1:100-500

交叉反应

交叉反应: Mouse (predicted: Human, Rat, Pig, Sheep, Cow, Chicken, Dog)

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靶标

基因名
NOS1
蛋白名
Nitric oxide synthase, brain
亚基
Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4. Interacts with VAC14 (By similarity). Interacts with SLC6A4.
亚细胞定位
Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
组织特异性
Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
翻译后修饰
Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).
相似性
Belongs to the NOS family.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain.
Contains 1 PDZ (DHR) domain.
功能
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

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