Big dynorphin Rabbit pAb (一抗) | Bioss
货号：bs-14473R
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概述
产品编号
bs-14473R
产品类型
农牧业/家禽抗体
英文名称
Big dynorphin Rabbit pAb
中文名称
强啡肽抗体
英文别名
ADCA; PENKB; SCA23; Dyn; PDYN_BOVIN; PDYN; Beta-neoendorphin-dynorphin; Preprodynorphin; PDYN_HUMAN; PDYN_MOUSE; PDYN_RAT; prodynorphin; spinocerebellar ataxia 23; preproenkephalin B; rimorphin; beta-neoendorphin; dynorphin; leu-enkephalin; leumorphin; neoendorphin-dynorphin-enkephalin prepropeptide
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Big dynorphin: 207-238/254
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
26 kDa
检测分子量
26 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Rabbit, Pig, Sheep, Cow, Horse | 1:500-2000 |
| IHC-P | Human, Rat | Mouse, Rabbit, Pig, Sheep, Cow, Horse | 1:100-500 |
| IHC-F | Human, Rat | Mouse, Rabbit, Pig, Sheep, Cow, Horse | 1:100-500 |
| IF | Human, Rat | Mouse, Rabbit, Pig, Sheep, Cow, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Horse)
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靶标
基因名
PDYN
蛋白名
Proenkephalin-B
亚细胞定位
Secreted.
翻译后修饰
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
疾病
Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
相似性
Belongs to the opioid neuropeptide precursor family.
功能
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
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