This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse, Rat
Human, Rabbit, Pig, Sheep, Cow, Horse
1:500-2000
交叉反应
交叉反应: Mouse, Rat (predicted: Human, Rabbit, Pig, Sheep, Cow, Horse)
相关产品
暂无相关产品
靶标
基因名
DUS2
蛋白名
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
亚细胞定位
Cytoplasmic and Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum.
相似性
Belongs to the dus family. Dus2 subfamily. Contains 1 DRBM (double-stranded RNA-binding) domain.
功能
DUS2L is a dihydrouridine synthase that catalyzes the reduction of the 5,6-double bond of a uridine residue on the displacement loop of tRNA. The resultant modified base, 5,6-dihydrouridine, appears to increase the conformational flexibility and dynamic motion of tRNA.