JAK1 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt | Bioss

bsm-54138R

重组兔单抗

JAK1 Recombinant Rabbit mAb

蛋白质酪氨酸激酶JAK-1重组兔单抗

AIIDE; JAK1A; JAK1B; JTK3; BAP004; C130039L05Rik; JAK1_HUMAN; JAK1; Janus kinase 1 (JAK-1); 2.7.10.2; JAK1_MOUSE; Janus kinase 1

Rabbit

A synthesized peptide derived from human JAK1: 625-660

IgG

Liquid

affinity purified by Protein A

Recombinant

2B12

133 kDa

130-135 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

激酶和磷酸酶（Kinases and Phosphatases）

Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

JAK1

Tyrosine-protein kinase JAK1

Interacts with FER (By similarity). Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB.

Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.

Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 2 protein kinase domains.
Contains 1 SH2 domain.

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.