蛋白质酪氨酸激酶JAK-1重组兔单抗

bsm-54138R

重组兔单抗

JAK1 Recombinant Rabbit mAb

蛋白质酪氨酸激酶JAK-1重组兔单抗

AIIDE; JAK1A; JAK1B; JTK3; BAP004; C130039L05Rik; JAK1_HUMAN; JAK1; Janus kinase 1 (JAK-1); 2.7.10.2; JAK1_MOUSE;

Rabbit

A synthesized peptide derived from human JAK1: 625-660

IgG

Liquid

affinity purified by Protein A

Recombinant

2B12

133 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

激酶和磷酸酶（Kinases and Phosphatases）

Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.