髓鞘少树突胶质细胞糖蛋白重组兔单抗
Rrmab®兔单抗
货号：bsm-54073R
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概述
产品编号
bsm-54073R
产品类型
重组兔单抗、农牧业/家禽抗体、mIHC精品抗体
英文名称
MOG Recombinant Rabbit mAb
中文名称
髓鞘少树突胶质细胞糖蛋白重组兔单抗
英文别名
BTN6; BTNL11; MOGIG2; NRCLP7; B230317G11Rik; MOG_HUMAN; MOG; MOG_MOUSE; MOG_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human MOG: 50-100/247
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7A1
理论分子量
24 kDa
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
以MOG35-55，多肽为抗原成功诱发EAE模型，该模型发病牢高，病理接近多发性硬化（MS），是研究MS的极为理想的动物模型。以MOG35-55，多肽为抗原成功诱发EAE模型，该模型发病牢高，病理接近多发性硬化（MS），是研究MS的极为理想的动物模型。
Luxol fast blue染色见EAE组脊髓白质脱髓鞘改变；雌、雄大、小鼠在发病率，发病时间，发病程度及病理改变上均无明显差别。结论 本研究以MOG35-55，多肽为抗原成功诱发EAE模型，该模型发病牢靠，病理接近多发性硬化（MS），是研究MS的极为理想的动物模型。
Luxol fast blue染色见EAE组脊髓白质脱髓鞘改变；雌、雄大、小鼠在发病率，发病时间，发病程度及病理改变上均无明显差别。结论 本研究以MOG35-55，多肽为抗原成功诱发EAE模型，该模型发病牢靠，病理接近多发性硬化（MS），是研究MS的极为理想的动物模型。
背景资料
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
MOG
蛋白名
Myelin-oligodendrocyte glycoprotein
亚基
Homodimer. May form heterodimers between the different isoforms.
亚细胞定位
Cell membrane; Multi-pass membrane protein (Potential).
组织特异性
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
疾病
Defects in MOG are the cause of narcolepsy type 7 (NRCLP7) [MIM:614250]. Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
相似性
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
功能
Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
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