IL-4 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-54002R

重组兔单抗

IL-4 Recombinant Rabbit mAb

白介素4重组兔单抗

BCGF-1; BCGF1; BSF-1; BSF1; IL-4; IL4_HUMAN; IL4; B-cell stimulatory factor 1 (BSF-1); Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra; IL4_MOUSE; B-cell IgG differentiation factor; B-cell growth factor 1; IGG1 induction factor; IL4_CANLF; interleukin 4; B_cell stimulatory factor 1; B cell growth factor 1

Rabbit

A synthesized peptide derived from human IL 4: 71-120

IgG

Liquid

affinity purified by Protein A

Recombinant

14G6

14 kDa

13 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

白介素-4仅限于活化T细胞，肥大细胞和噬碱性白细胞。
IL-4对各种淋巴细胞，单核—巨噬细胞，甚至纤维母细胞和上皮细胞都有促生长和分化的作用。

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

IL4

Interleukin-4

Secreted.

Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

Belongs to the IL-4/IL-13 family.

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.