Bim Rabbit pAb (一抗) | Bioss
货号：bs-25552R
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概述
产品编号
bs-25552R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
Bim Rabbit pAb
中文名称
细胞死亡调解子抗体
英文别名
BAM; BIM; BOD; B2L11_HUMAN; BCL2L11; Bcl2-L-11; Bcl2-interacting mediator of cell death;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Bim: 1-100/198
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
22 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cell Death > Apoptosis > Apoptosis Markers > Bcl 2 family
Cancer > Cell Death > Apoptosis > Metabolism
Cancer > Invasion/microenvironment > Apoptosis > Bcl 2 family
Cancer > Oncoproteins/suppressors > Oncoproteins > Cell survival & death
Cell Biology > Apoptosis > Intracellular > Associated Proteins
Cell Biology > Apoptosis > Intracellular > Bcl2 Family
Immunology > Innate Immunity > Macrophage / Inflamm.
Metabolism > Pathways and Processes > Metabolism processes > Apoptosis
Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease
Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Bim是Bcl-2家族BH3-only亚家族的成员,是一种重要的凋亡调节蛋白，具有助凋亡活性作用。Bim广泛表达于正常细胞,对防御自身免疫、维持造血细胞稳态有重要意义,并具有肿瘤抑制因子活性.Bim的生理作用与它调节细胞凋亡的功能有关。
背景资料
Bim, Bcl-2 interacting mediator of cell death, is a pro-apoptotic protein belonging to the Bcl2 family of proteins containing a Bcl2 homology domain 3 (BH3). It is proapoptotic and exerts its effects by interacting with prosurvival members of the Bcl2 family like Bcl2, BclxL and Bclw. Bim is sequestered in an inactive conformation through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release Bim from microtubules, allowing inhibitory binding to anti-apoptotic Bcl-2 family members and subsequent iniation of apoptosis.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | Mouse, Rat, Pig, Cow, Dog | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Pig, Cow, Dog | 1:400-800 |
| IF | Human | Mouse, Rat, Pig, Cow, Dog | 1:100-500 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Pig, Cow, Dog)
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靶标
基因名
BCL2L11
蛋白名
Bcl-2-like protein 11
亚基
Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK.
亚细胞定位
Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion.
组织特异性
Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
相似性
Belongs to the Bcl-2 family.
功能
Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
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