Corin Rabbit pAb (一抗) | Bioss
货号：bs-7685R
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概述
产品编号
bs-7685R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
Corin Rabbit pAb
中文名称
心脏特异性丝氨酸蛋白酶抗体
英文别名
ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10; CORIN_HUMAN; CORIN; Heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme; Transmembrane protease serine 10; 3.4.21.-; Q566K6_MOUSE; CORIN_MOUSE; Low density lipoprotein receptor-related protein 4; CORIN_RAT; corin, serine peptidase; corin, serine protease
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Corin: 165-245/1042 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
115 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Corin was first described as a trypsin-like serine proteinase in the heart which processed pro-atrial natriuretic peptide into the active form ANP. Corin cleaves pro-ANP at Arg98/Ser-99, and blocking Corin message inhibits pro-ANP processing. Null mutant mice lacking Corin develop hypertension, and a series of missense mutations have been identified in humans with high blood pressure and hypertension. Corin is a member of the type-II transmembrane serine proteinases, such as Hepsin, Epitheliasin, Matriptase and enteropeptidase. The Corin domain structure includes a cytoplasmic domain, a transmembrane domain, a spacer region, a frizzled-like domain, 5 LDL Receptor-like domains, another frizzled-like domain, 3 more LDLR-like repeats, a SRCR (Scavenger Receptor-Cysteine Rich) domain (also called macrophage scavenger-like domain), and finally the trypsin-like serine proteinase domain. The complex domain structure puts Corin into the “mosaic” TMPRSS family, so named because of the wide variety of domains.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| Flow-Cyt | Human | Mouse, Rat, Pig, Dog, Horse | 1ug/Test |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Pig, Dog, Horse)
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靶标
基因名
CORIN
蛋白名
Atrial natriuretic peptide-converting enzyme
亚细胞定位
Cell membrane; Single-pass type II membrane protein. Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble form produced following cleavage by ADAM10. Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage. Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.
组织特异性
Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus.
翻译后修饰
N-glycosylated; required for processing and activation.
相似性
Belongs to the peptidase S1 family.
Contains 2 FZ (frizzled) domains.
Contains 7 LDL-receptor class A domains.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain.
Contains 2 FZ (frizzled) domains.
Contains 7 LDL-receptor class A domains.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain.
功能
Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Isoform 2: has weaker endopeptidase activity compared to isoform 1.
Isoform 2: has weaker endopeptidase activity compared to isoform 1.
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