RUNX1 / AML1 + RUNX3 + RUNX2 Rabbit pAb (一抗) | Bioss
货号：bs-18598R
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概述
产品编号
bs-18598R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
RUNX1 / AML1 + RUNX3 + RUNX2 Rabbit pAb
中文名称
RUNX1 / AML1 + RUNX3 + RUNX2抗体
英文别名
AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA; AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2; EVI-1; PEBP2aB; PEBP2alpha; AML2; CBFA3; PEBP2aC; Cbf; Cbfa-1; LS3; Pebp2a1; Pebpa2a; CBF-alpha-2; Pebp2a2; Pebpa2b; Pebp2a3; Rx3; PEA2-alpha; PEBP2-alpha; RUNX1_HUMAN; RUNX1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2 (CBF-alpha-2); Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit (PEA2-alpha B | PEBP2-alpha B); SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; RUNX3_HUMAN; RUNX3; Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3 (CBF-alpha-3); Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit (PEA2-alpha C | PEBP2-alpha C); SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; RUNX2_HUMAN; RUNX2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1 (CBF-alpha-1); Oncogene AML-3; Osteoblast-specific transcription factor 2 (OSF-2); Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A | PEBP2-alpha A); SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; PEBP2A; RUNX1_MOUSE; RUNX2_MOUSE; RUNX3_MOUSE; RUNX1_RAT; RUNX2_RAT; RUNX family transcription factor 1; acute myeloid leukemia 1; runt-related transcription factor 1; runt related transcription factor 1; aml1 oncogene
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human RUNX1 + RUNX3 + RUNX2
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
45-57 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Oncoproteins/suppressors > Oncoproteins > Transcription factors
Developmental Biology > Organogenesis > Hematopoietic system development
Developmental Biology > Organogenesis > Skeletal development > Bone
Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding
Epigenetics and Nuclear Signaling > Transcription > Other factors
Epigenetics and Nuclear Signaling > Transcription > Transcription Factors
Neuroscience > Neurology process > Neurogenesis
Stem Cells > Hematopoietic Progenitors > Hemangioblast
Stem Cells > Hematopoietic Progenitors > Intracellular Molecules
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | Mouse, Rat, Rabbit, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Rabbit, Cow, Dog, Horse | 1:100-500 |
| IF | Human | Mouse, Rat, Rabbit, Cow, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Rabbit, Cow, Dog, Horse)
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靶标
基因名
RUNX1
蛋白名
Runt-related transcription factor 1
亚基
Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and ALYREF/THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with KAT6A and KAT6B. Interacts with SUV39H1, leading to abrogation of transactivating and DNA-binding properties of RUNX1. Interacts with YAP1. Interacts with HIPK2 (By similarity). Interaction with CDK6 prevents myeloid differentiation, reducing its transcription transactivation activity.
亚细胞定位
Nucleus.
组织特异性
Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
翻译后修饰
Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A.
Methylated.
Phosphorylated in Ser-249 Thr-273 and Ser-276 by HIPK2 when associated with CBFB and DNA. This phosphorylation promotes subsequent EP300 phosphorylation.
Methylated.
Phosphorylated in Ser-249 Thr-273 and Ser-276 by HIPK2 when associated with CBFB and DNA. This phosphorylation promotes subsequent EP300 phosphorylation.
疾病
Note=A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with EAP or MECOM.
Note=A chromosomal aberration involving RUNX1/AML1 is found in childhood acute lymphoblastic leukemia (ALL). Translocation t(12;21)(p13;q22) with TEL. The translocation fuses the 3'-end of TEL to the alternate 5'-exon of AML-1H.
Note=A chromosomal aberration involving RUNX1 is found in acute leukemia. Translocation t(11,21)(q13;q22) that forms a MACROD1-RUNX1 fusion protein.
Defects in RUNX1 are the cause of familial platelet disorder with associated myeloid malignancy (FPDMM) [MIM:601399]. FPDMM is an autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
Note=A chromosomal aberration involving RUNX1/AML1 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
Note=A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelomonocytic leukemia. Inversion inv(21)(q21;q22) with USP16.
Note=A chromosomal aberration involving RUNX1/AML1 is found in childhood acute lymphoblastic leukemia (ALL). Translocation t(12;21)(p13;q22) with TEL. The translocation fuses the 3'-end of TEL to the alternate 5'-exon of AML-1H.
Note=A chromosomal aberration involving RUNX1 is found in acute leukemia. Translocation t(11,21)(q13;q22) that forms a MACROD1-RUNX1 fusion protein.
Defects in RUNX1 are the cause of familial platelet disorder with associated myeloid malignancy (FPDMM) [MIM:601399]. FPDMM is an autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
Note=A chromosomal aberration involving RUNX1/AML1 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
Note=A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelomonocytic leukemia. Inversion inv(21)(q21;q22) with USP16.
相似性
Contains 1 Runt domain.
功能
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.
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