GCLC Rabbit pAb (一抗) | Bioss

bs-23393R

宠物抗体、模式动物抗体、农牧业/家禽抗体

GCLC Rabbit pAb

γ谷氨酰半胱氨酸合成酶抗体

CNSHA7; GCL; GCS; GLCL; GLCLC; D9Wsu168e; GLCL-H; Ggcs-hs; GSH1_HUMAN; GCLC; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase; 6.3.2.2; GSH1_MOUSE; GSH1_RAT;

Rabbit

KLH conjugated synthetic peptide derived from human GCLC: 351-450/637

IgG

Liquid

affinity purified by Protein A

Polyclonal

73 kDa

73 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The GCLC gene consists of 16 exons and encodes the 636 amino acid protein g-GCSc (g-glutamylcysteine synthetase heavy subunit), also designated g-L-glutamate-L-cysteine ligase catalytic subunit (GLCLC). g-GCSc is expressed in hemocytes, brain, liver and kidney. g-GCSc associates with a regulatory or modifier subunit, g-GCSm (g-glutamylcysteine synthetase light subunit), to form a heterodimer, g-GCS. g-GCS is the first enzyme involved and the rate determining step in glutathione biosynthesis. Oxidants, cadium and methyl mercury upregulate the transcription of g-GCS. H2O2 regulation depends on the Yap1 protein and the presence of glutamate, glutamine and lysine. Cadium regulates transcription through proteins Met-4, Met-31 and Met-32. Cbf1, a DNA binding protein, inhibits transcription of g-GCS. Chemopreventive compounds cause increased levels of g-GCSc in kidney tissues, which may protect against chemically induced carcinogenesis. A His370Leu amino acid change in g-GCSc causes deficiencies in activity which are responsible for hemolytic anemia and low red blood cell glutathione levels. Defects in GCLC are the cause of hemolytic anemia.