CD3G Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF | Bioss

bsm-60390R

重组兔单抗

CD3G Recombinant Rabbit mAb

CD3G重组兔单抗

CD3-GAMMA; CD3GAMMA; IMD17; T3G; Ctg-3; Ctg3; CD3G; CD3G_BOVIN; T-cell receptor T3 gamma chain; CD3G_HUMAN; CD3G_MOUSE; CD3G_PIG; CD3G_RAT; CD3G_SHEEP; CD3 gamma subunit of T-cell receptor complex; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, gamma (CD3-TCR complex); CD3g molecule; T-cell surface glycoprotein CD3 gamma chain

Rabbit

KLH conjugated synthetic peptide derived from human CD3G

IgG

Liquid

affinity purified by Protein A

Recombinant

B6H3

20 kDa

25 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

CD3G

T-cell surface glycoprotein CD3 gamma chain

membrane

Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8 (PubMed:2470098). Phosphorylated also by PKC; leading to the TCR complex down-regulation (PubMed:8187769).

Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 1 ITAM domain.

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.