S100P Recombinant Rabbit mAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt | Bioss

bsm-60370R

重组兔单抗、病理级抗体、mIHC精品抗体

S100P Recombinant Rabbit mAb

S100钙结合蛋白P重组兔单抗

MIG9; S100P_HUMAN; S100P; Migration-inducing gene 9 protein (MIG9); Protein S100-E; S100 calcium-binding protein P; S100E; S100 calcium binding protein P

Rabbit

A synthesized peptide derived from human S100P: 71-95

IgG

Liquid

affinity purified by Protein A

Recombinant

E10A6

10 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq]

S100P

Protein S100-P

Homodimer and heterodimer with S100A1. Interacts with S100PBP and S100Z. Interacts with CACYBP in a calcium-dependent manner. Dimeric form binds to and activates EZR/Ezrin by unmasking its F-actin binding sites. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.

Nucleus. Cytoplasm. Colocalizes with S100PBP in the nucleus.

etected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.

Belongs to the S-100 family.
Contains 2 EF-hand domains.

May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).