NR1H4 Rabbit pAb (一抗) - WB,Flow-Cyt,ICC/IF | Bioss

bs-12867R

宠物抗体、农牧业/家禽抗体

NR1H4 Rabbit pAb

胆汁酸受体抗体

BAR; FXR; HRR-1; HRR1; PFIC5; RIP14; Rxrip14; NR1H4_HUMAN; NR1H4; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14 (RXR-interacting protein 14); Q3V1T8_MOUSE; Retinoid X receptor-interacting protein 14; NR1H4_MOUSE; Q5XI75_RAT; NR1H4_RAT; nuclear receptor subfamily 1, group H, member 4; farnesoid X receptor; bile acid receptor

Rabbit

KLH conjugated synthetic peptide derived from human FXR/Bile Acid Receptor NR1H4: 175-280/486

IgG

Liquid

affinity purified by Protein A

Polyclonal

56 kDa

50 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.