BIG1 Rabbit pAb (一抗) | Bioss

bs-12866R

宠物抗体、农牧业/家禽抗体

BIG1 Rabbit pAb

ARF鸟苷酸交换因子BIG1抗体

ARFGEP1; BIG1; DEDISB; P200; D130059B05Rik; D730028O18Rik; BIG1_HUMAN; ARFGEF1; Brefeldin A-inhibited GEP 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1; p200 ARF guanine nucleotide exchange factor; p200 ARF-GEP1; ARF guanine nucleotide exchange factor 1; ADP ribosylation factor guanine nucleotide exchange factor 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); Brefeldin A-inhibited guanine nucleotide-exchange protein 1

Rabbit

KLH conjugated synthetic peptide derived from human BIG1/ARFGEF1: 1-200/1849

IgG

Liquid

affinity purified by Protein A

Polyclonal

209 kDa

209 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.