ITGAE/CD103 Recombinant Rabbit mAb (一抗) - IHC-P,IHC-F,IF | Bioss

bsm-60226R

重组兔单抗、mIHC精品抗体

ITGAE/CD103 Recombinant Rabbit mAb

整合素αE重组兔单抗

CD103; HUMINAE; ITAE_HUMAN; ITGAE; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; integrin subunit alpha E; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); antigen CD103; human mucosal lymphocyte antigen 1, alpha polypeptide

Rabbit

KLH conjugated synthetic peptide derived from human ITGAE/CD103

IgG

Liquid

affinity purified by Protein A

Recombinant

C4G1

110/128 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

ITGAE

Integrin alpha-E

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Membrane; Single-pass type I membrane protein.

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.