配对盒基因5重组兔单抗
Rrmab®兔单抗
货号：bsm-60221R
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概述
产品编号
bsm-60221R
产品类型
重组兔单抗、病理级抗体
英文名称
PAX5 Recombinant Rabbit mAb
中文名称
配对盒基因5重组兔单抗
英文别名
ALL3; BSAP; PAX-5; EBB-1; KLP; PAX5_HUMAN; PAX5; B-cell-specific transcription factor (BSAP); PAX5_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human PAX5
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
G7C4
理论分子量
42 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
同源结构域蛋白（Homeodomain Proteins）
PAX-5属于转录抑制因子。在胚胎发育和肿瘤生长中起关键作用。其突变和某些肿瘤的发病有关。Pax-5基因是B细胞生成和B细胞发育的重要转录因子，是B细胞系特异性激活蛋白。在B细胞早期发育阶段，Pax-5能影响CD19、CD20等B细胞特异性基因的表达。它主要分布于前B细胞和成熟B细胞。该蛋白对B细胞和神经元的发育有重要作用。
背景资料
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Rat | 1:500-2000 |
| IHC-P | Human, Rat | 1:100-500 | |
| IHC-F | Human, Rat | 1:100-500 | |
| IF | Human, Rat | 1:100-500 | |
| ICC/IF | Human, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Rat
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靶标
基因名
PAX5
蛋白名
Paired box protein Pax-5
亚基
Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4. Interacts with ETS1, altering its DNA-binding properties.
亚细胞定位
Nucleus.
组织特异性
Expressed at early B-cell differentiation, in the developing CNS and in adult testis.
翻译后修饰
O-glycosylated (Probable).
疾病
Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.
相似性
Contains 1 paired domain.
功能
May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
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