DNA polymerase delta Rabbit pAb (一抗) | Bioss

bs-7416R

DNA polymerase delta Rabbit pAb

DNA聚合酶δ 抗体

50kDa; p50; po1D2; DPOD2_BOVIN; POLD2; DNA polymerase delta subunit p50; DPOD2_HUMAN; DPOD2_MOUSE; DPOD2_RAT;

Rabbit

KLH conjugated synthetic peptide derived from Human DNA polymerase delta: 101-200/469

IgG

Liquid

affinity purified by Protein A

Polyclonal

51 kDa

51 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol α, β, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8).