CD79b Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,ICC/IF | Bioss

bsm-60240R

重组兔单抗

CD79b Recombinant Rabbit mAb

CD79b重组兔单抗

AGM6; B29; IGB; Igbeta; Ig-beta; CD79B_HUMAN; CD79B; B-cell-specific glycoprotein B29; Immunoglobulin-associated B29 protein; CD79B_MOUSE; CD79b molecule; CD79B antigen (immunoglobulin-associated beta); CD79b molecule, immunoglobulin-associated beta; B-cell antigen receptor complex-associated protein beta chain

Rabbit

A synthesized peptide derived from human CD79b: 3-54

IgG

Liquid

affinity purified by Protein A

Recombinant

C7H9

23 kDa

42-50 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

CD79B

B-cell antigen receptor complex-associated protein beta chain

Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

B-cells.

Phosphorylated on tyrosine upon B-cell activation.

Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 1 ITAM domain.

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.