CD79b重组兔单抗
Rrmab®兔单抗
货号：bsm-60240R
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概述
产品编号
bsm-60240R
产品类型
重组兔单抗
英文名称
CD79b Recombinant Rabbit mAb
中文名称
CD79b重组兔单抗
英文别名
AGM6; B29; IGB; Igbeta; Ig-beta; CD79B_HUMAN; CD79B; B-cell-specific glycoprotein B29; Immunoglobulin-associated B29 protein; CD79B_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human CD79b: 3-54
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
C7H9
理论分子量
23 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Immunology > Adaptive Immunity > B Cells > CD
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:1000-5000 | |
| Flow-Cyt | Human | 1:100-200 | |
| ICC/IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
CD79B
蛋白名
B-cell antigen receptor complex-associated protein beta chain
亚细胞定位
Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
组织特异性
B-cells.
翻译后修饰
Phosphorylated on tyrosine upon B-cell activation.
疾病
Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
相似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 1 ITAM domain.
Contains 1 ITAM domain.
功能
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
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