alpha Actinin 4 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF | Bioss

bsm-60423R

重组兔单抗

alpha Actinin 4 Recombinant Rabbit mAb

α-辅肌动蛋白4重组兔单抗

ACTININ-4; FSGS; FSGS1; ACTN4_HUMAN; ACTN4; Non-muscle alpha-actinin 4; ACTN4_MOUSE; ACTN4_RAT;

Rabbit

KLH conjugated synthetic peptide derived from human alpha Actinin 4

IgG

Liquid

affinity purified by Protein A

Recombinant

A12H9

105 kDa

108 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008].